Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
KM Fujihara, BZ Zhang, TD Jackson, MO Ogunkola… - Science …, 2022 - science.org
The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent
remains unresolved, although the clinical development of eprenetapopt focuses on its …
remains unresolved, although the clinical development of eprenetapopt focuses on its …
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Even in the setting of optimal resuscitation in high-income countries severe sepsis and
septic shock have a mortality of 20–40%, with antibiotic resistance dramatically increasing …
septic shock have a mortality of 20–40%, with antibiotic resistance dramatically increasing …
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem.
Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG …
Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG …
CD98 defines a metabolically flexible, proinflammatory subset of low‐density neutrophils in systemic lupus erythematosus
KR Martin, JA Day, JA Hansen… - Clinical and …, 2023 - Wiley Online Library
Background Low‐density neutrophils (LDN) are a distinct subset of neutrophils rarely
detected in healthy people but appear in the blood of patients with autoimmune diseases …
detected in healthy people but appear in the blood of patients with autoimmune diseases …
Hemolytic-Pred: A machine learning-based predictor for hemolytic proteins using position and composition-based features
G Perveen, F Alturise, T Alkhalifah… - Digital …, 2023 - journals.sagepub.com
Objective The objective of this study is to propose a novel in-silico method called Hemolytic-
Pred for identifying hemolytic proteins based on their sequences, using statistical moment …
Pred for identifying hemolytic proteins based on their sequences, using statistical moment …
A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565
Rhizobia are nitrogen-fixing bacteria that engage in symbiotic relationships with plant hosts
but can also persist as free-living bacteria in the soil and rhizosphere. Here, we show that …
but can also persist as free-living bacteria in the soil and rhizosphere. Here, we show that …
[HTML][HTML] Integrating the Transcriptome and Proteome to Postulate That TpiA and Pyk Are Key Enzymes Regulating the Growth of Mycoplasma Bovis
F Yang, M Yang, F Liu, Y Qi, Y Guo, S He - Microorganisms, 2024 - mdpi.com
Mycoplasma bovis is a global problem for the cattle industry due to its high infection rates
and associated morbidity, although its pathophysiology is poorly understood. In this study …
and associated morbidity, although its pathophysiology is poorly understood. In this study …
Mycoplasma bovis membrane protein MilA is a multifunctional lipase with novel lipid and glycosaminoglycan binding activity
JY Adamu, NK Wawegama… - Infection and …, 2020 - Am Soc Microbiol
The survival, replication, and virulence of mycoplasmas depend on their ability to capture
and import host-derived nutrients using poorly characterized membrane proteins. Previous …
and import host-derived nutrients using poorly characterized membrane proteins. Previous …
Genes required for survival and proliferation of Mycoplasma bovis in association with host cells
CK Premachandre, PK Vaz, S Sharma… - Applied and …, 2024 - Am Soc Microbiol
Mycoplasma bovis is an important emerging pathogen of cattle and bison, but our
understanding of the genetic basis of its interactions with its host is limited. The aim of this …
understanding of the genetic basis of its interactions with its host is limited. The aim of this …
[HTML][HTML] Reversion of mutations in a live mycoplasma vaccine alters its metabolism
SM Klose, DP De Souza, JF Disint, DM Andrews… - Vaccine, 2023 - Elsevier
The live attenuated temperature sensitive vaccine strain MS-H (Vaxsafe® MS, Bioproperties
Pty. Ltd., Australia) is widely used to control disease associated with M. synoviae infection in …
Pty. Ltd., Australia) is widely used to control disease associated with M. synoviae infection in …