Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-
like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

In metazoans, transition from fetal to adult heart is accompanied by a switch in energy
metabolism-glycolysis to fatty acid oxidation. The molecular factors regulating this metabolic …

Post-transcriptional adenosine-to-inosine RNA editing mediated by adenosine deaminase
acting on RNA1 (ADAR1) promotes cancer progression and therapeutic resistance …

Stroke produces a limited process of neural repair. Axonal sprouting in cortex adjacent to the
infarct is part of this recovery process, but the signal that initiates axonal sprouting is not …

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate
decisions. Here we sought to determine how Notch pathway activation inhibits the …

Neurologic complications are commonly regarded as irreversible impairments that stem from
limited potential of regeneration of the central nervous system (CNS). On the other side, the …

MicroRNAs (miRNAs) are major drivers of cell fate specification and differentiation. The post-
transcriptional regulation of key molecular factors by microRNAs contributes to the …

Abstract Embryonal tumor with Multilayered Rosettes (ETMR) is a relatively rare but typically
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …