Background and objectives: Despite reductions in prevalence in recent years, tobacco
smoking remains one of the main preventable causes of ill-health and premature death …

Aims In this exciting era of gene discovery, we review evidence from family, adoption and
twin studies that examine the genetic basis for addiction. With a focus on the classical twin …

Background Considerable evidence has been reported that tobacco use could cause
alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at …

Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …

Across a wide range of studies, researchers often conclude that the home environment and
children's outcomes are causally linked. In contrast, behavioral genetic studies show that …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …

Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth
of information on physical and mental health, lifestyle, and personality in adolescents and …

Tobacco use is the leading preventable cause of death worldwide and is a major risk factor
for cardiovascular disease (CVD). Both prevention of smoking initiation among youth and …

Context Understanding the mechanisms underlying nicotine addiction to develop more
effective treatment is a public health priority. Research consistently shows that nicotine …