Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA
molecules direct the addition of DNA methylation to specific DNA sequences. The RdDM …

The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …