Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across …
Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis
In the present review, we summarize work from our as well as other groups related to the
characterization of bacterial T cell epitopes, with a specific focus on two important …
characterization of bacterial T cell epitopes, with a specific focus on two important …
In silico identification of supertypes for class II MHCs
IA Doytchinova, DR Flower - The Journal of Immunology, 2005 - journals.aai.org
The development of epitope-based vaccines, which have wide population coverage, is
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …
[HTML][HTML] The impact of amino acid variability on alloreactivity defines a functional distance predictive of permissive HLA-DPB1 mismatches in hematopoietic stem cell …
P Crivello, L Zito, F Sizzano, E Zino, M Maiers… - Biology of Blood and …, 2015 - Elsevier
A major challenge in unrelated hematopoietic stem cell transplantation (HSCT) is the
prediction of permissive HLA mismatches, ie, those associated with lower clinical risks …
prediction of permissive HLA mismatches, ie, those associated with lower clinical risks …
Crystal structure of HLA-DP2 and implications for chronic beryllium disease
S Dai, GA Murphy, F Crawford… - Proceedings of the …, 2010 - National Acad Sciences
Chronic beryllium disease (CBD) is a fibrotic lung disorder caused by beryllium (Be)
exposure and is characterized by granulomatous inflammation and the accumulation of Be …
exposure and is characterized by granulomatous inflammation and the accumulation of Be …
HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families
MD Varney, AM Valdes, JA Carlson, JA Noble… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE To determine the relative risk associated with DPA1 and DPB1 alleles and
haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of …
haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of …
Peptide binding prediction for the human class II MHC allele HLA-DP2: a molecular docking approach
Background MHC class II proteins bind oligopeptide fragments derived from proteolysis of
pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells …
pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells …
Immunopeptidome analysis of HLA-DPB1 allelic variants reveals new functional hierarchies
P van Balen, MGD Kester, W de Klerk… - The Journal of …, 2020 - journals.aai.org
HLA-DP alleles can be classified into functional T cell epitope (TCE) groups. TCE-1 and
TCE-2 are clearly defined, but TCE-3 still represents an heterogeneous group. Because …
TCE-2 are clearly defined, but TCE-3 still represents an heterogeneous group. Because …
Genetic susceptibility and immune-mediated destruction in beryllium-induced disease
AP Fontenot, LA Maier - Trends in immunology, 2005 - cell.com
Chronic beryllium disease (CBD) is a hypersensitivity disorder caused by beryllium
exposure in the workplace and is characterized by the accumulation of beryllium-specific …
exposure in the workplace and is characterized by the accumulation of beryllium-specific …