Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

It has long been appreciated that the experience of pain is highly variable between
individuals. Pain results from activation of sensory receptors specialized to detect actual or …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Agonists for the μ-opioid receptor are powerful analgesics and are highly addictive;
however, the contribution of the δ-and κ-opioid and opioid receptor-like receptors to …

Chronic pain, whether the result of nerve trauma or persistent inflammation, is a debilitating
condition that exerts a high social cost in terms of productivity, economic impact and quality …

A deficit of endogenous pain inhibitory systems has been suggested to contribute to some
chronic pain conditions, one of them being fibromyalgia. The aim of the investigation was to …

Chronic pain and depressive illness are debilitating disease states that are variably resistant
to currently available therapeutic agents. Animal models of chronic pain are associated with …

Objective The groin pain experienced by patients with hip osteoarthritis (OA) is often
accompanied by areas of referred pain and changes in skin sensitivity. We aimed to identify …

Objectives: There is evidence that education on pain physiology can have positive effects on
pain, disability, and catastrophization in patients with chronic musculoskeletal pain …