Polymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs.
Many different PM have been designed and evaluated over the years, and some of them …

After more than 20 years of intensive investigations, gene therapy has become one of the
most promising strategies for treating genetic diseases. However, the lack of ideal delivery …

DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …

(Figure 1a). Taking advantage of the high cytosolic esterase activity in HeLa cancer cells but
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …

The complex function of living systems is dictated by their inherent cooperative response to
multiple external stimuli which induce dynamic changes in their physicochemical properties …

Since its emergence, semiconductor nanoparticles known as quantum dots (QDs) have
drawn considerable attention and have quickly extended their applicability to numerous …

Nonviral gene delivery with synthetic cationic polymeric vectors is widely recognized as an
attractive alternative to viral gene delivery, which suffers from inherent immunogenicity and …

Although many of these polycation–DNA nanoparticles display relatively high levels of
transfection efficiency in cell culture, their performance in vivo has been disappointing.[2] …

Nanoparticle-mediated delivery of therapeutics holds great potential for the diagnosis and
treatment of a wide range of diseases. Significant advances have been made in the design …

Gene therapy provides a promising paradigm for the treatment of various acquired or
congenital diseases such as cystic fibrosis, severe combined immunodeficiency, diabetes …