Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges

MD Berry, RR Gainetdinov, MC Hoener… - Pharmacology & …, 2017 - Elsevier
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …

Shock–classification and pathophysiological principles of therapeutics

ON Kislitsina, JD Rich, JE Wilcox… - Current cardiology …, 2019 - ingentaconnect.com
The management of patients with shock is extremely challenging because of the myriad of
possible clinical presentations in cardiogenic shock, septic shock and hypovolemic shock …

The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats

A Ferragud, AD Howell, CF Moore, TL Ta… - …, 2017 - nature.com
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of
obesity and eating disorders, as well as of the recently proposed disorder of food addiction …

The biology of addiction

B MacNicol - Canadian Journal of Anesthesia/Journal canadien d' …, 2017 - Springer
In this narrative review, the neurobiological mechanisms underlying substance abuse and
addiction are discussed with a particular emphasis on the mechanisms that promote …

Role of neurochemicals in the interaction between the microbiota and the immune and the nervous system of the host organism

AV Oleskin, BA Shenderov, VS Rogovsky - Probiotics and Antimicrobial …, 2017 - Springer
This work is concerned with the role of evolutionary conserved substances,
neurotransmitters, and neurohormones, within the complex framework of the microbial …

Thyronamines and derivatives: physiological relevance, pharmacological actions, and future research directions

CS Hoefig, R Zucchi, J Köhrle - Thyroid, 2016 - liebertpub.com
Thyronamines (3-T1AM, T0AM) are endogenous compounds probably derived from L-
thyroxine or its intermediate metabolites. Combined activities of intestinal deiodinases and …

Actions of trace amines in the brain-gut-microbiome axis via trace amine-associated receptor-1 (TAAR1)

K Bugda Gwilt, DP González, N Olliffe, H Oller… - Cellular and molecular …, 2020 - Springer
Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are
widely studied for their involvement in the pathogenesis of neuropsychiatric disorders …

Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects

JF Liu, R Seaman Jr, JN Siemian, R Bhimani… - …, 2018 - nature.com
Nicotine addiction and abuse remains a global health issue. To date, the fundamental
neurobiological mechanism of nicotine addiction remains incompletely understood. Trace …

Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS)

K Blum, D Baron, T McLaughlin, MS Gold - Journal of the Neurological …, 2020 - Elsevier
The consensus of the current literature strongly supports the concept that brain
neurotransmitters, and second messengers involved in the net release of dopamine in the …