Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim… - Experimental & molecular …, 2021 - nature.com
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
Protein arginine methyltransferases and cancer
Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …
genomes, the protein products of which catalyse three types of arginine methylation …
Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …
regulation, play important roles in regulating a variety of cellular physiological and …
N6-Methyl-Adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function
Abstract N6-methyl-adenosine (m6A) is one of the most common and abundant
modifications on RNA molecules present in eukaryotes. However, the biological significance …
modifications on RNA molecules present in eukaryotes. However, the biological significance …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
Histone methylation and the DNA damage response
Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …
an imbalance in which can promote diseases including cancer. In the presence of DNA …
Cellular consequences of arginine methylation
BM Lorton, D Shechter - Cellular and Molecular Life Sciences, 2019 - Springer
Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …
The emerging role of PRMT6 in cancer
Z Chen, J Gan, Z Wei, M Zhang, Y Du, C Xu… - Frontiers in …, 2022 - frontiersin.org
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …
regulation of gene expression through methylating histone or non-histone proteins, and …
Protein arginine methylation of non-histone proteins and its role in diseases
Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate
arginine residues on histones and other proteins. PRMTs play a crucial role in influencing …
arginine residues on histones and other proteins. PRMTs play a crucial role in influencing …