Overcoming cancer resistance to platinum drugs by inhibiting cholesterol metabolism
Y Wang, L Cai, H Li, H Chen, T Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
Drug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes
may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key …
may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key …
[HTML][HTML] Peptides released from bovine α-lactalbumin by simulated digestion alleviated free fatty acids-induced lipid accumulation in HepG2 cells
H Chen, X Qi, K Guan, Y Gu, R Wang, Q Li… - Journal of Functional …, 2021 - Elsevier
Our previous study showed that α-lactalbumin (α-LA) has a regulatory effect on lipid
metabolism in obese mice. In this study, we performed simulated gastrointestinal digestion …
metabolism in obese mice. In this study, we performed simulated gastrointestinal digestion …
Neuroprotective effect of Saroglitazar on scopolamine-induced Alzheimer's in rats: insights into the underlying mechanisms
G Sandeep Ganesh, P Konduri, AS Kolusu… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD) is one of the most prevalent and progressive neurodegenerative
disorders, hallmarked by increased amyloid-β deposition and enhanced oxidative load in …
disorders, hallmarked by increased amyloid-β deposition and enhanced oxidative load in …
Development of heterocyclic PPAR ligands for potential therapeutic applications
The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and
PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the …
PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the …
Improved glycemic status, insulin resistance and inflammation after receiving oral oleoylethanolamide supplement in people with prediabetes: a randomized …
E Pouryousefi, M Javadi, S Hashemipour… - Diabetology & Metabolic …, 2022 - Springer
Background The anti-inflammatory properties of cannabinoids have been shown. This study
was conducted to assess effect of oleoylethanolamide (OEA) supplementation on glycemic …
was conducted to assess effect of oleoylethanolamide (OEA) supplementation on glycemic …
Cyclosorus Terminans Extract Alleviates Neuroinflammation in Insulin Resistant Rats
TT Oo, W Pratchayasakul, K Chattipakorn… - Molecular …, 2023 - Springer
High-fat diet consumption for an extended period causes obesity, systemic metabolic
disturbance, and brain insulin resistance, resulting in neuroinflammation. Although the …
disturbance, and brain insulin resistance, resulting in neuroinflammation. Although the …
The synergistic ameliorative activity of peroxisome proliferator‐activated receptor‐alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal …
OK Idowu, OO Oluyomi, OO Faniyan, OO Dosumu… - Ibrain, 2022 - Wiley Online Library
Insulin resistance (IR) is a risk factor for metabolic disorders and neurodegeneration.
Peroxisome proliferator‐activated receptor (PPAR) agonists have been proven to mitigate …
Peroxisome proliferator‐activated receptor (PPAR) agonists have been proven to mitigate …
[PDF][PDF] Development of Heterocyclic PPAR Ligands for Potential Therapeutic Applications. Pharmaceutics 2022, 14, 2139
The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and
PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the …
PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the …
Role of PPAR modulators on seizure control and neurobehavior in status epilepticus model in rats
S Sinha, SC Sarangi, D Sharma, SS Pattnaik, A Arora… - 2024 - researchsquare.com
This study explored the impact of peroxisome proliferator-activated receptor modulators
(PPAR-m) on seizure control and epileptogenesis in a lithium-pilocarpine-induced status …
(PPAR-m) on seizure control and epileptogenesis in a lithium-pilocarpine-induced status …