[HTML][HTML] Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
JH Zhao, D Stacey, N Eriksson… - Nature …, 2023 - nature.com
Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome …
To identify genetic influences on inflammation-related proteins, we conducted a genome …
Causality-enriched epigenetic age uncouples damage and adaptation
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …
age but often lack causal insights. By harnessing large-scale genetic data through …
[HTML][HTML] Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
[HTML][HTML] Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways
P Demela, N Pirastu, B Soskic - Nature Communications, 2023 - nature.com
Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci
associated with immune-mediated diseases. To assess the extent of the genetic sharing …
associated with immune-mediated diseases. To assess the extent of the genetic sharing …
[HTML][HTML] Investigation of genetic determinants of cognitive change in later life
Cognitive decline is a major health concern and identification of genes that may serve as
drug targets to slow decline is important to adequately support an aging population. Whilst …
drug targets to slow decline is important to adequately support an aging population. Whilst …
[HTML][HTML] The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive
function is associated with increased dementia and stroke risk. The mechanisms underlying …
function is associated with increased dementia and stroke risk. The mechanisms underlying …
[HTML][HTML] Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
J Yarmolinsky, JW Robinson, D Mariosa, V Karhunen… - …, 2024 - thelancet.com
Background Tumour-promoting inflammation is a" hallmark" of cancer and conventional
epidemiological studies have reported links between various inflammatory markers and …
epidemiological studies have reported links between various inflammatory markers and …
SharePro: an accurate and efficient genetic colocalization method accounting for multiple causal signals
Motivation Colocalization analysis is commonly used to assess whether two or more traits
share the same genetic signals identified in genome-wide association studies (GWAS), and …
share the same genetic signals identified in genome-wide association studies (GWAS), and …
Investigating the association between genetically proxied circulating levels of immune checkpoint proteins and cancer survival: protocol for a Mendelian …
T Bate, RM Martin, J Yarmolinsky, PC Haycock - BMJ open, 2024 - bmjopen.bmj.com
Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
[HTML][HTML] Protocol: Investigating the association between genetically proxied circulating levels of immune checkpoint proteins and cancer survival: protocol for a …
T Bate, RM Martin, J Yarmolinsky, PC Haycock - BMJ Open, 2024 - ncbi.nlm.nih.gov
Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …