This review focuses on the role of prenatal hypoxia in the development of brain functions in
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …

Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with
high heritability rates. The contribution of genetic factors to the etiology of these disorders is …

Defining the environmental context in which genes enhance disease susceptibility can
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …

It is well accepted that events that interfere with the normal program of neuronal
differentiation and brain maturation may be relevant for the etiology of psychiatric disorders …

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes
neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the …

Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …

Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

MRI has enhanced our capacity to understand variations in brain structure and function
conferred by the genome. We identified 60 studies that report associations between DNA …

Importance Schizophrenia is a severe mental disorder in which epigenetic mechanisms may
contribute to illness risk. Epigenetic profiles can be derived from blood cells, but to our …