[HTML][HTML] NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
A Abderrazak, T Syrovets, D Couchie, K El Hadri… - Redox biology, 2015 - Elsevier
IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …
inflammasomes. Different inflammasome complexes have been described to date. While all …
Pathogenesis of chronic Chagas disease: macrophages, mitochondria, and oxidative stress
Abstract Purpose of Review Trypanosoma cruzi is the causative agent of Chagas disease.
Decades after initial infection,~ 30% of individuals can develop chronic chagasic …
Decades after initial infection,~ 30% of individuals can develop chronic chagasic …
[HTML][HTML] A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers
Monomethylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of
enhancers and promoters, although its function is unknown. Here, we uncover roles for …
enhancers and promoters, although its function is unknown. Here, we uncover roles for …
The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties
G Raicevic, M Najar, B Stamatopoulos, C De Bruyn… - Cellular …, 2011 - Elsevier
Mesenchymal stromal cells (MSC) can be expanded from different sources. We compared
the influence of inflammation and TLR ligation on the phenotype and function of MSC …
the influence of inflammation and TLR ligation on the phenotype and function of MSC …
Regulated extracellular choline acetyltransferase activity—the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway
S Vijayaraghavan, A Karami, S Aeinehband… - PloS one, 2013 - journals.plos.org
Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable
cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system …
cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system …
Supraphysiological levels of testosterone induce vascular dysfunction via activation of the NLRP3 inflammasome
Background: Both supraphysiological and subphysiological testosterone levels are
associated with increased cardiovascular risk. Testosterone consumption at …
associated with increased cardiovascular risk. Testosterone consumption at …
Caspase-1/ASC inflammasome-mediated activation of IL-1β–ROS–NF-κB pathway for control of Trypanosoma cruzi replication and survival is dispensable in NLRP3 …
In this study, we have utilized wild-type (WT), ASC−/−, and NLRP3−/− macrophages and
inhibition approaches to investigate the mechanisms of inflammasome activation and their …
inhibition approaches to investigate the mechanisms of inflammasome activation and their …
Toll-like receptor 5 promotes the neurogenesis from embryonic stem cells and adult hippocampal neural stem cells in mice
KJ Seong, S Choi, HG Lee, JH Rhee, JH Lee… - Stem Cells, 2022 - academic.oup.com
Toll-like receptors (TLRs) make a crucial contribution to the innate immune response. TLR5
was expressed in embryoid body derived from mouse embryonic stem cells (mESCs) and …
was expressed in embryoid body derived from mouse embryonic stem cells (mESCs) and …
Immunogenicity of embryonic stem cell-derived progenitors after transplantation
K English, KJ Wood - Current opinion in organ transplantation, 2011 - journals.lww.com
Although ESCs and ESC-derived progenitors appear to exert some level of immune
privilege in specific circumstances, these allogeneic cells are indeed recognized by the …
privilege in specific circumstances, these allogeneic cells are indeed recognized by the …
Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA
Embryonic stem cells (ESCs) are considered to be a promising cell source for regenerative
medicine because of their unlimited capacity for self-renewal and differentiation. However …
medicine because of their unlimited capacity for self-renewal and differentiation. However …