Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …

Protein expression levels depend on the balance between their synthesis and degradation
rates. Even quiescent (G0) cells display a continuous turnover of proteins, despite protein …

SOX 2 and OCT 4 are pioneer transcription factors playing a key role in embryonic stem (ES)
cell self‐renewal and differentiation. How temporal fluctuations in their expression levels …

Background Inference of gene regulatory networks from gene expression data has been a
long-standing and notoriously difficult task in systems biology. Recently, single-cell …

Cell state transitions are prevalent in biology, playing a fundamental role in development,
homeostasis and repair. Dysregulation of cell state transitions can lead to or occur in a wide …

Tracking individual cells has allowed a new understanding of cellular behavior in human
health and disease by adding a dynamic component to the already complex heterogeneity …

Proteins are in a dynamic state of synthesis and degradation and their half-lives can be
adjusted under various circumstances. However, most commonly used approaches to …

The transduction of extracellular signals through signaling pathways that culminate in a
transcriptional response is central to many biological processes. However, quantitative …

As key cellular processes are dynamic in nature and underlie sophisticated spatial and
temporal orchestration within living cells and whole organisms “seeing is believing” has …

Precise spatiotemporal regulation of gene expression is essential for development and
homeostasis of complex organisms. This is achieved in large part by sequence-specific …