Functions of 'A disintegrin and metalloproteases (ADAMs)'in the mammalian nervous system
HE Hsia, J Tüshaus, T Brummer, Y Zheng… - Cellular and Molecular …, 2019 - Springer
Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …
Leucine rich repeat proteins: sequences, mutations, structures and diseases
N Matsushima, S Takatsuka, H Miyashita… - Protein and peptide …, 2019 - ingentaconnect.com
Mutations in the genes encoding Leucine Rich Repeat (LRR) containing proteins are
associated with over sixty human diseases; these include high myopia, mitochondrial …
associated with over sixty human diseases; these include high myopia, mitochondrial …
The LGI1–ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function
KL Lovero, Y Fukata, AJ Granger… - Proceedings of the …, 2015 - National Acad Sciences
Synapse development is coordinated by a number of transmembrane and secreted proteins
that come together to form synaptic organizing complexes. Whereas a variety of …
that come together to form synaptic organizing complexes. Whereas a variety of …
Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
A Yamagata, Y Miyazaki, N Yokoi… - Nature …, 2018 - nature.com
Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand–receptor
complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a …
complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a …
Molecular and cellular mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system
MH van Coevorden-Hameete, E de Graaff… - Autoimmunity …, 2014 - Elsevier
Over the last decade multiple autoantigens located on the plasma membrane of neurons
have been identified. Neuronal surface antigens include molecules directly involved in …
have been identified. Neuronal surface antigens include molecules directly involved in …
LGI proteins in the nervous system
L Kegel, E Aunin, D Meijer, JR Bermingham Jr - ASN neuro, 2013 - journals.sagepub.com
The development and function of the vertebrate nervous system depend on specific
interactions between different cell types. Two examples of such interactions are synaptic …
interactions between different cell types. Two examples of such interactions are synaptic …
Insights into the mechanisms of epilepsy from structural biology of LGI1–ADAM22
A Yamagata, S Fukai - Cellular and Molecular Life Sciences, 2020 - Springer
Epilepsy is one of the most common brain disorders, which can be caused by abnormal
synaptic transmissions. Many epilepsy-related mutations have been identified in synaptic …
synaptic transmissions. Many epilepsy-related mutations have been identified in synaptic …
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
J Ramirez-Franco, K Debreux, J Extremet, Y Maulet… - Brain, 2022 - academic.oup.com
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with
encephalitis who present with frequent focal seizures and a pattern of amnesia consistent …
encephalitis who present with frequent focal seizures and a pattern of amnesia consistent …
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures
Abstract Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly
expressed in the brain, and involved in central nervous system development and …
expressed in the brain, and involved in central nervous system development and …
Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures
Abstract Leucin-rich, glioma inactivated 1 (LGI1) is a secreted protein linked to human
seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are …
seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are …