Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the
construction of complex molecules. With their debut in 2005, these catalysts have been …

Covering: up to August 2015 Alkaloids account for some of the most beautiful and
biologically active natural products. Although they are usually classified along biosynthetic …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

Inspired by their potential biosynthesis, we have developed divergent total syntheses of
seven monoterpene indole alkaloids including mersicarpine, leuconodines B and D …

Conspectus Polycyclic natural products are an inexhaustible source of medicinal agents,
and their complex molecular architecture renders challenging synthetic targets where …

Natural products (NPs) have been used as traditional medicines since antiquity. With more
than 1060 estimated compounds with molecular weights less than 500 Da representing …

The powerful insecticidal and multi-drug-resistance-reversing activities displayed by the
stemofoline group of alkaloids render them promising lead structures for further …

We herein report the first total syntheses of several bis-β-carboline alkaloids, picrasidines G,
S, R, and T, and natural product-like derivatives in a divergent manner. Picrasidines G, S …