Fat of the gut: epithelial phospholipids in inflammatory bowel diseases

LV Boldyreva, MV Morozova, SS Saydakova… - International journal of …, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

M Kovatcheva, E Melendez, D Chondronasiou… - Nature …, 2023 - nature.com
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …

Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages

SR Hyam, IA Lee, W Gu, KA Kim, JJ Jeong… - European journal of …, 2013 - Elsevier
Seeds of Arctium lappa, containing arctigenin and its glycoside arctiin as main constituents,
have been used as a diuretic, anti-inflammatory and detoxifying agent in Chinese traditional …

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

Y Yasui, M Hosokawa, N Mikami, K Miyashita… - Chemico-biological …, 2011 - Elsevier
Astaxanthin (AX) is one of the marine carotenoid pigments, which possess powerful
biological antioxidant, anti-inflammatory and anti-cancer properties. The purpose of this …

Anti-inflammatory action of angiotensin 1-7 in experimental colitis

MA Khajah, MM Fateel, KV Ananthalakshmi… - PLoS …, 2016 - journals.plos.org
Background There is evidence to support a role for angiotensin (Ang) 1–7 in reducing the
activity of inflammatory signaling molecules such as MAPK, PKC and SRC. Enhanced …

Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling

BD Sahu, JM Kumar, R Sistla - The Journal of nutritional biochemistry, 2016 - Elsevier
Fisetin, a dietary flavonoid, is commonly found in many fruits and vegetables. Although
studies indicate that fisetin has an anti-inflammatory property, little is known about its effects …

Phosphoinositide 3‐kinase p110γ in immunity

C Costa, EL Martin‐Conte, E Hirsch - IUBMB life, 2011 - Wiley Online Library
The rapid and accurate response of leukocytes to environmental cues is critical for a proper
inflammatory reaction to foreign particles or invading microbes. In the last decade, the signal …

Preventive effects of Goji berry on dextran-sulfate-sodium-induced colitis in mice

Y Kang, Y Xue, M Du, MJ Zhu - The Journal of nutritional biochemistry, 2017 - Elsevier
Goji berry (Lycium barbarum) exerts immune modulation and suppresses inflammation in
vitro and in vivo. We hypothesized that Goji berry had beneficial effects on dextran sulfate …

Rigosertib potently protects against colitis-associated intestinal fibrosis and inflammation by regulating PI3K/AKT and NF-κB signaling pathways

F Rahmani, F Asgharzadeh, A Avan, F Barneh… - Life sciences, 2020 - Elsevier
Aims Rigosertib (RGS) is a PI3K inhibitor that exerts protective effects against tumor
progression and cancer-related inflammation. This study was aimed to explore the …

[HTML][HTML] Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways

H Lee, YS Son, MO Lee, JW Ryu, K Park, O Kwon… - Theranostics, 2020 - ncbi.nlm.nih.gov
Several phase 1/2 clinical trials showed that low-dose interleukin-2 (IL-2) treatment is a safe
and effective strategy for the treatment of chronic graft-versus-host disease, hepatitis C virus …