Lipids in extracellular vesicles: What can be learned about membrane structure and function?
T Skotland, A Llorente… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Extracellular vesicles, such as exosomes, can be used as interesting models to study the
structure and function of biological membranes as these vesicles contain only one …
structure and function of biological membranes as these vesicles contain only one …
Protein homeostasis in aging and cancer
XQ Chen, T Shen, SJ Fang, XM Sun, GY Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Exosomal lipid PI4P regulates small extracellular vesicle secretion by modulating intraluminal vesicle formation
Membrane lipids play vital roles in small extracellular vesicle (sEV) biogenesis. However,
the function of various lipids in the biogenesis of sEVs is still poorly understood …
the function of various lipids in the biogenesis of sEVs is still poorly understood …
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system
A Somogyi, ED Kirkham, E Lloyd-Evans… - Journal of Cell …, 2023 - journals.biologists.com
Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …
[HTML][HTML] Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm
Body temperature in homeothermic animals does not remain constant but displays a regular
circadian fluctuation within a physiological range (eg, 35° C–38.5° C in mice), constituting a …
circadian fluctuation within a physiological range (eg, 35° C–38.5° C in mice), constituting a …
Metabolic routing maintains the unique fatty acid composition of phosphoinositides
YJ Kim, N Sengupta, M Sohn, A Mandal… - EMBO …, 2022 - embopress.org
Phosphoinositide lipids (PPIn) are enriched in stearic‐and arachidonic acids (38: 4) but how
this enrichment is established and maintained during phospholipase C (PLC) activation is …
this enrichment is established and maintained during phospholipase C (PLC) activation is …
Plasma membrane phosphatidylinositol (4, 5)-bisphosphate is critical for determination of epithelial characteristics
K Kanemaru, M Shimozawa, M Kitamata… - Nature …, 2022 - nature.com
Epithelial cells provide cell-cell adhesion that is essential to maintain the integrity of
multicellular organisms. Epithelial cell-characterizing proteins, such as epithelial junctional …
multicellular organisms. Epithelial cell-characterizing proteins, such as epithelial junctional …
A global LC–MS2‐based methodology to identify and quantify anionic phospholipids in plant samples
M Genva, L Fougère, D Bahammou… - The Plant …, 2024 - Wiley Online Library
SUMMARY Anionic phospholipids (PS, PA, PI, PIPs) are low‐abundant phospholipids with
impactful functions in cell signaling, membrane trafficking and cell differentiation processes …
impactful functions in cell signaling, membrane trafficking and cell differentiation processes …
A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling
A Kourkoulou, O Martzoukou, R Fischer… - Communications …, 2024 - nature.com
Depending on their phosphorylation status, derivatives of phosphatidylinositol play
important roles in vesicle identity, recognition and intracellular trafficking processes. In …
important roles in vesicle identity, recognition and intracellular trafficking processes. In …