Extracellular vesicles, such as exosomes, can be used as interesting models to study the
structure and function of biological membranes as these vesicles contain only one …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

Membrane lipids play vital roles in small extracellular vesicle (sEV) biogenesis. However,
the function of various lipids in the biogenesis of sEVs is still poorly understood …

Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …

Body temperature in homeothermic animals does not remain constant but displays a regular
circadian fluctuation within a physiological range (eg, 35° C–38.5° C in mice), constituting a …

Phosphoinositide lipids (PPIn) are enriched in stearic‐and arachidonic acids (38: 4) but how
this enrichment is established and maintained during phospholipase C (PLC) activation is …

Epithelial cells provide cell-cell adhesion that is essential to maintain the integrity of
multicellular organisms. Epithelial cell-characterizing proteins, such as epithelial junctional …

SUMMARY Anionic phospholipids (PS, PA, PI, PIPs) are low‐abundant phospholipids with
impactful functions in cell signaling, membrane trafficking and cell differentiation processes …

Depending on their phosphorylation status, derivatives of phosphatidylinositol play
important roles in vesicle identity, recognition and intracellular trafficking processes. In …