Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called
microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers …

Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as
much as 3% of all colon and endometrial cancers. The identification and management of …

Lynch syndrome, an autosomal dominant inherited disorder, is caused by inactivating
mutations involving DNA mismatch repair (MMR) genes. This leads to profound genetic …

Objective Determine factors impacting the uptake of genetic counseling and results of
genetic testing following universal tumor testing for Lynch syndrome in patients with …

Evidence suggests that a significant proportion of individuals referred to cancer genetic
counselling (GC) do not attend, and thus may not be engaged in adequate cancer risk …

Introduction Lynch Syndrome (LS) represents the hereditary condition that is most frequently
associated with endometrial cancer (EC). The aim of this study is to assess the presence of …

Patient-centred care is tailored to the needs of patients and is necessary for better health
outcomes, especially for individuals with limited health literacy (LHL). However, its …

In the era of precision medicine, patients must manage the uncertainty caused by
ambiguous genetic information. To aid health practitioners in effectively communicating …

Lynch syndrome (LS) is the most common heritable colorectal cancer (CRC) syndrome,
accounting for approximately 3% of CRC cases in the USA each year. LS results from a …

Universal screening for Lynch syndrome (LS) among all cases of colorectal cancer (CRC)
could increase the diagnosis of LS and reduce morbidity and mortality of LS-associated …