This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

Background Clinical interpretation of the large number of rare variants identified by high
throughput sequencing (HTS) technologies is challenging. The aim of this study was to …

Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …

Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis
through to the adult heart. Although traditionally known for its role in energy transduction and …

Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction,
and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome …

Objective: Discuss evidence referring to the genetic role in congenital heart diseases,
whether chromosomic alterations or monogenic diseases. Data source: LILACS, PubMed …

Aims Coarctation of the aorta (CoA) accounts for 4–8% of congenital heart defects (CHDs)
and confers substantial morbidity despite treatment. It is increasingly recognized as a highly …

Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …