MAFLD: A multisystem disease
RM Pipitone, C Ciccioli, G Infantino… - Therapeutic …, 2023 - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches
HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …
and the most common type of dementia in aged people. Neuropathological lesions of AD …
Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease
A Salminen, A Kauppinen… - Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …
Oxidative Stress and β-Amyloid Protein in Alzheimer's Disease
Z Cai, B Zhao, A Ratka - Neuromolecular medicine, 2011 - Springer
Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …
Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus
G M. Ashraf, N H. Greig, T A. Khan… - CNS & Neurological …, 2014 - benthamdirect.com
In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …
appropriately folded. Their amino acid sequence encodes the relevant information required …
Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease
K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …
neurodegenerative disorder associated with cognition, memory and behavioural …
Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
L Ismaili, B Refouvelet, M Benchekroun, S Brogi… - Progress in …, 2017 - Elsevier
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2
The recent new contagion coronavirus 2019 (COVID-19) disease is a new generation of
severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 which infected millions …
severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 which infected millions …