MAFLD: A multisystem disease

RM Pipitone, C Ciccioli, G Infantino… - Therapeutic …, 2023 - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

R Leon, AG Garcia… - Medicinal research …, 2013 - Wiley Online Library
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches

HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

A Salminen, A Kauppinen… - Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Oxidative Stress and β-Amyloid Protein in Alzheimer's Disease

Z Cai, B Zhao, A Ratka - Neuromolecular medicine, 2011 - Springer
Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus

G M. Ashraf, N H. Greig, T A. Khan… - CNS & Neurological …, 2014 - benthamdirect.com
In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

L Ismaili, B Refouvelet, M Benchekroun, S Brogi… - Progress in …, 2017 - Elsevier
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2

H Khelfaoui, D Harkati, BA Saleh - Journal of Biomolecular …, 2021 - Taylor & Francis
The recent new contagion coronavirus 2019 (COVID-19) disease is a new generation of
severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 which infected millions …