The largely dominant meritocratic paradigm of highly competitive Western cultures is rooted
on the belief that success is mainly due, if not exclusively, to personal qualities such as …

Mathematical and computational modeling enables biologists to integrate data from
observations and experiments into a theoretical framework. In this review, we describe how …

Intestinal tract development is a coordinated process involving signaling among the
progenitors and developing cells from all three germ layers. Development of endoderm …

The receptor tyrosine kinase Ret plays a critical role in regulating enteric nervous system
(ENS) development. Ret is important for proliferation, migration, and survival of enteric …

Cells of the vagal neural crest (NC) form most of the enteric nervous system (ENS) by a
colonising wave in the embryonic gut, with high cell proliferation and differentiation. Enteric …

Scientific progress during the last three decades has greatly profited from our advances in
understanding complex systems. Fundamental modeling approaches were considerably …

Patients with Hirschsprung disease (HSCR) do not always receive a genetic diagnosis after
routine screening in clinical practice. One of the reasons for this could be that the causal …

In this paper we review some recent results about the efficiency of random strategies for
complex systems. Inspired by physical systems, we discuss several successful examples of …

We quantified cell population increase in the quail embryo enteric nervous system (ENS)
from E2. 5 (about 1500 cells) to E12 (about 8 million cells). We then probed ENS …

Intestinal epithelium development depends on epigenetic modifications, but whether that is
also the case for other intestinal tract cell types remains unclear. We found that functional …