Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

The primary etiology of a diverse range of cardiomyopathies is now understood to be
genetic, creating a new paradigm for targeting treatments on the basis of the underlying …

Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart
and blood vessels and remain a major cause of death and disability worldwide. CVD …

Amyloidosis is a group of diverse disorders caused by misfolded proteins that aggregate into
insoluble fibrils and ultimately cause organ damage. In medical practice, amyloidosis …

The heart, once considered a mere blood pump, is now recognized as a multifunctional
metabolic and endocrine organ. Its function is tightly regulated by various metabolic …

With the escalating prevalence of cardiovascular diseases, the substantial socioeconomic
burden on healthcare systems is intensifying. Accumulating empirical evidence underscores …

Title. HDAC6 Inhibitors and Uses Thereof Patent Publication Number. WO 2021/021979 A2
Publication Date. February 4, 2021 Priority Application. US 62/880,284 Priority Date. July 30 …

This study characterizes the plasma levels and composition of SDS-resistant aggregates
(SRAs) in patients with heart failure with preserved ejection fraction (HFpEF) to infer …

Background Proteostasis impairment and the consequent increase of amyloid burden in the
myocardium have been associated with heart failure (HF) development and poor prognosis …