[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer

D Müller, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Novel diagnostic biomarkers in colorectal cancer

AL Zygulska, P Pierzchalski - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

[HTML][HTML] Colorectal cancer: from prevention to personalized medicine

G Binefa, F Rodríguez-Moranta, À Teule… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a very heterogeneous disease that is caused by the interaction
of genetic and environmental factors. CRC develops through a gradual accumulation of …

Next-generation stool DNA test accurately detects colorectal cancer and large adenomas

DA Ahlquist, H Zou, M Domanico, DW Mahoney… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Technical advances have led to stool DNA (sDNA) tests that might
accurately detect neoplasms on both sides of the colorectum. We assessed colorectal …

Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer

SC Glöckner, M Dhir, JM Yi, KE McGarvey… - Cancer research, 2009 - AACR
We have used a gene expression array–based strategy to identify the methylation of tissue
factor pathway inhibitor 2 (TFPI2), a potential tumor suppressor gene, as a frequent event in …

[HTML][HTML] Colon cancer screening methods: 2023 update

M Jayasinghe, O Prathiraja, D Caldera, R Jena… - Cureus, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. National
screening guidelines have been implemented to identify and remove precancerous polyps …

Molecular detection of colorectal neoplasia

DA Ahlquist - Gastroenterology, 2010 - Elsevier
A variety of noninvasive molecular approaches to colorectal cancer screening are emerging
with potential to improve screening effectiveness and user-friendliness. These approaches …

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

AEK Ibrahim, MJ Arends, AL Silva, AH Wyllie, L Greger… - Gut, 2011 - gut.bmj.com
Background and aims Although aberrant methylation of key genes in the progression of
colorectal neoplasia has been reported, no model-based analysis of the incremental …

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas

GE Lind, SA Danielsen, T Ahlquist, MA Merok… - Molecular cancer, 2011 - Springer
Background The presence of cancer-specific DNA methylation patterns in epithelial
colorectal cells in human feces provides the prospect of a simple, non-invasive screening …