Highlights•Hsp90 is a molecular chaperone that modulates the function of many client
proteins.•Morphogenesis is an important Candida albicans virulence trait.•Hsp90 regulates …

Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …

We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

HtpG, a bacterial homolog of the eukaryotic 90 kDa heat-shock protein (Hsp90), represents
the simplest member of the heat shock protein family. While the significance of Hsp90 in …

Background Metschnikowia bicuspidata is a pathogenic yesst that can cause disease in
many different economic aquatic animal species. In recent years, there was a new disease …

Pathogenic fungi are an increasing public health concern. The emergence of antifungal
resistance coupled with the scarce antifungal arsenal highlights the need for novel …

Fungal pathogens are emerging threats to global health with the rise of incidence
associated with climate change and increased geographical distribution; factors also …

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent
candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and …

Fungi are a diverse group of eukaryotic organisms that infect humans, animals, and plants.
To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host's …

There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a
leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal …