Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

UB Pandey, CD Nichols - Pharmacological reviews, 2011 - ASPET
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Circadian Organization of Behavior and Physiology in Drosophila

R Allada, BY Chung - Annual review of physiology, 2010 - annualreviews.org
Circadian clocks organize behavior and physiology to adapt to daily environmental cycles.
Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely …

Multifarious functions of the fragile X mental retardation protein

JK Davis, K Broadie - Trends in Genetics, 2017 - cell.com
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

Prevalence, nature, and correlates of sleep problems among children with fragile X syndrome based on a large scale parent survey

R Kronk, EE Bishop, M Raspa, JO Bickel, DA Mandel… - Sleep, 2010 - academic.oup.com
Abstract Study Objectives: This study reports on current child sleep difficulties reported by
parents of children with Fragile X syndrome (FXS). We address prevalence and type of sleep …

Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us

AR Santos, AK Kanellopoulos, C Bagni - Learning & memory, 2014 - learnmem.cshlp.org
The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet …

The novel gene twenty-four defines a critical translational step in the Drosophila clock

C Lim, J Lee, C Choi, VL Kilman, J Kim, SM Park… - Nature, 2011 - nature.com
Daily oscillations of gene expression underlie circadian behaviours in multicellular
organisms. While attention has been focused on transcriptional and post-translational …

Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates

K Niu, L Xiang, Y Jin, Y Peng, F Wu… - Nucleic acids …, 2019 - academic.oup.com
Double-stranded DNAs are usually present in the form of linear B-form double-helix with the
base pairs of adenine (A) and thymine (T) or cytosine (C) and guanine (G), but G-rich DNA …

Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes

R El Fatimy, S Tremblay, AY Dury, S Solomon… - PLoS …, 2012 - journals.plos.org
Fragile X syndrome is caused by the absence of the Fragile X Mental Retardation Protein
(FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles …

RNA‐binding proteins in eye development and disease: implication of conserved RNA granule components

S Dash, AD Siddam, CE Barnum… - Wiley …, 2016 - Wiley Online Library
The molecular biology of metazoan eye development is an area of intense investigation.
These efforts have led to the surprising recognition that although insect and vertebrate eyes …

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P

RL Coffee Jr, CR Tessier… - Disease models & …, 2010 - journals.biologists.com
Fragile X syndrome (FXS), resulting solely from the loss of function of the human fragile X
mental retardation 1 (hFMR1) gene, is the most common heritable cause of mental …