Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
UB Pandey, CD Nichols - Pharmacological reviews, 2011 - ASPET
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …
model organism for understanding molecular mechanisms of human diseases. Many basic …
Circadian Organization of Behavior and Physiology in Drosophila
Circadian clocks organize behavior and physiology to adapt to daily environmental cycles.
Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely …
Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely …
Multifarious functions of the fragile X mental retardation protein
JK Davis, K Broadie - Trends in Genetics, 2017 - cell.com
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …
results from the loss of Fragile X mental retardation protein (FMRP). This …
Prevalence, nature, and correlates of sleep problems among children with fragile X syndrome based on a large scale parent survey
Abstract Study Objectives: This study reports on current child sleep difficulties reported by
parents of children with Fragile X syndrome (FXS). We address prevalence and type of sleep …
parents of children with Fragile X syndrome (FXS). We address prevalence and type of sleep …
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us
AR Santos, AK Kanellopoulos, C Bagni - Learning & memory, 2014 - learnmem.cshlp.org
The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet …
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet …
The novel gene twenty-four defines a critical translational step in the Drosophila clock
C Lim, J Lee, C Choi, VL Kilman, J Kim, SM Park… - Nature, 2011 - nature.com
Daily oscillations of gene expression underlie circadian behaviours in multicellular
organisms. While attention has been focused on transcriptional and post-translational …
organisms. While attention has been focused on transcriptional and post-translational …
Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates
K Niu, L Xiang, Y Jin, Y Peng, F Wu… - Nucleic acids …, 2019 - academic.oup.com
Double-stranded DNAs are usually present in the form of linear B-form double-helix with the
base pairs of adenine (A) and thymine (T) or cytosine (C) and guanine (G), but G-rich DNA …
base pairs of adenine (A) and thymine (T) or cytosine (C) and guanine (G), but G-rich DNA …
Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes
R El Fatimy, S Tremblay, AY Dury, S Solomon… - PLoS …, 2012 - journals.plos.org
Fragile X syndrome is caused by the absence of the Fragile X Mental Retardation Protein
(FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles …
(FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles …
RNA‐binding proteins in eye development and disease: implication of conserved RNA granule components
S Dash, AD Siddam, CE Barnum… - Wiley …, 2016 - Wiley Online Library
The molecular biology of metazoan eye development is an area of intense investigation.
These efforts have led to the surprising recognition that although insect and vertebrate eyes …
These efforts have led to the surprising recognition that although insect and vertebrate eyes …
Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P
RL Coffee Jr, CR Tessier… - Disease models & …, 2010 - journals.biologists.com
Fragile X syndrome (FXS), resulting solely from the loss of function of the human fragile X
mental retardation 1 (hFMR1) gene, is the most common heritable cause of mental …
mental retardation 1 (hFMR1) gene, is the most common heritable cause of mental …