[HTML][HTML] Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Hepatocellular carcinoma in the setting of alcohol-related liver disease

N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …

Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …

[HTML][HTML] MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

B Donati, P Dongiovanni, S Romeo, M Meroni… - Scientific reports, 2017 - nature.com
Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular
carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C> T …

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

A Yang, EP Mottillo - Biochemical Journal, 2020 - portlandpress.com
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

[PDF][PDF] Leveraging human genetics to identify potential new treatments for fatty liver disease

S Romeo, A Sanyal, L Valenti - Cell metabolism, 2020 - cell.com
Fatty liver disease (FLD), including its more severe pathologies, namely steatohepatitis,
hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease …

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy

YX Xian, JP Weng, F Xu - Chinese medical journal, 2021 - mednexus.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

C Pirazzi, L Valenti, BM Motta, P Pingitore… - Human molecular …, 2014 - academic.oup.com
Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate
cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme …

[HTML][HTML] Insights into nonalcoholic fatty-liver disease heterogeneity

M Arrese, JP Arab, F Barrera… - Seminars in liver …, 2021 - thieme-connect.com
The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient
population. Although in many patients the primary driver is metabolic dysfunction, a complex …