[HTML][HTML] Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors
O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …
Update on NAFLD genetics: from new variants to the clinic
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
Hepatocellular carcinoma in the setting of alcohol-related liver disease
N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
[HTML][HTML] MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular
carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C> T …
carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C> T …
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics
A Yang, EP Mottillo - Biochemical Journal, 2020 - portlandpress.com
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …
organelles by professional storage cells called adipocytes. These lipids are mobilized …
[PDF][PDF] Leveraging human genetics to identify potential new treatments for fatty liver disease
Fatty liver disease (FLD), including its more severe pathologies, namely steatohepatitis,
hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease …
hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease …
MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy
YX Xian, JP Weng, F Xu - Chinese medical journal, 2021 - mednexus.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …
worldwide, placing an increasing burden on human health. NAFLD is a complex …
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate
cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme …
cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme …
[HTML][HTML] Insights into nonalcoholic fatty-liver disease heterogeneity
M Arrese, JP Arab, F Barrera… - Seminars in liver …, 2021 - thieme-connect.com
The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient
population. Although in many patients the primary driver is metabolic dysfunction, a complex …
population. Although in many patients the primary driver is metabolic dysfunction, a complex …