Valid inference for machine learning-assisted genome-wide association studies

J Miao, Y Wu, Z Sun, X Miao, T Lu, J Zhao, Q Lu - Nature Genetics, 2024 - nature.com
Abstract Machine learning (ML) has become increasingly popular in almost all scientific
disciplines, including human genetics. Owing to challenges related to sample collection and …

[HTML][HTML] Bone and Entheseal Targets for Growth Factors in Diffuse Idiopathic Skeletal Hyperostosis

GO Littlejohn - Seminars in Arthritis and Rheumatism, 2024 - Elsevier
Introduction Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the
adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for …

Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration

Y Gao, Y Zou, D Sokolowskei, X Xing, RJ Tower, Z Lai… - Molecular Therapy, 2024 - cell.com
Intense inflammatory response impairs bone marrow mesenchymal stem cell (BMSC)-
mediated bone regeneration, with transforming growth factor (TGF)-β1 being the most highly …

Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH)

DE Fournier, MC Battie, CA Séguin - RMD open, 2024 - rmdopen.bmj.com
Objectives The purpose of our study was to characterise spatiotemporal features of disease
progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase …

Osteophyte Bridge Formation Correlates with Vascular Calcification and Cardiovascular Disease in Diffuse Idiopathic Skeletal Hyperostosis

R Hirota, A Teramoto, M Yoshimoto… - Journal of Clinical …, 2023 - mdpi.com
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy
characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic …

Prevalence and characteristics of osseous bridging between vertebral bodies in the cervical spine: A skeletal study

D Ezra, R Mader, A Yosef, L Kalichman… - Clinical …, 2025 - Wiley Online Library
Osseous bridging (OB) in three or more segments of motions (SOMs) of the mobile spine
was initially defined as diffuse idiopathic skeletal hyperostosis (DISH), located particularly in …

Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH

Z He, NTC Tung, Y Yahara, H Makino, T Yasuda… - …, 2024 - academic.oup.com
Objective To investigate the relationship between the severity and morphology of
heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum …

Aging of the Spine: Characterizing genetic and physiological determinants of spinal curvature

FM Wang, JG Ruby, A Sethi, M Veras, N Telis… - medRxiv, 2024 - medrxiv.org
Increased spinal curvature is one of the most recognizable aging traits in the human
population. However, despite high prevalence, the etiology of this condition remains poorly …

肥胖症与弥漫性特发性骨肥厚症的关系

孔鹿鸣, 赵弟乾, 白文哲, 李念虎 - 中国组织工程研究, 2025 - cjter.com
肥胖症与弥漫性特发性骨肥厚症的关系 Page 1 Chinese Journal of Tissue Engineering
Research|Vol 29|No.17|June 2025|3705 中国组织工程研究 Chinese Journal of Tissue …

Unveiling the distinctive ossification patterns of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis using computed tomography three-dimensional …

S Liao, J Zhu, L Cheng, Z Zhao, X Ji, J Zhang… - …, 2024 - academic.oup.com
Objective To quantitatively analyse the morphological characteristics of osteophytes in DISH
and syndesmophytes in AS, and summarize different ossification patterns to help identify the …