Neurodegenerative diseases (NDs) are a type of common chronic progressive disorders
characterized by progressive damage to specific cell populations in the nervous system …

Itaconate is an immunoregulatory metabolite produced by the mitochondrial enzyme
immune-responsive gene 1 (IRG1) in inflammatory macrophages. We recently identified an …

Immunometabolism plays a central role in sustaining immune system functionality and
preserving physiological homeostasis within the organism. During the differentiation and …

In vivo single-cell approaches have transformed our understanding of the immune
populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass …

Almost 16% of the global population is affected by neurological disorders, including
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …

Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates
the development of osteoporosis, which is the leading risk factor of disability in the elderly …

The ability of mitochondria to transform the energy we obtain from food into cell
phosphorylation potential has long been appreciated. However, recent decades have seen …

Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and
immunoregulatory activity has attracted much attention in the field of immunometabolism …

Sepsis is a severe global health issue with high mortality rates, and sepsis-associated
encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the …

In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC)
mobilization in response to Plasmodium infection. The authors showed that elevated levels …