Recent advances in therapeutic chalcones

L Ni, CQ Meng, JA Sikorski - Expert Opinion on Therapeutic Patents, 2004 - Taylor & Francis
Naturally-occurring and synthetic chalcone compounds have shown promising biological
activity and safety profiles and have the potential to be developed as, or more properly …

[HTML][HTML] Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …

QSAR studies on chalcones and flavonoids as anti-tuberculosis agents using genetic function approximation (GFA) method

PM Sivakumar, SKG Babu, D Mukesh - … and pharmaceutical bulletin, 2007 - jstage.jst.go.jp
Design of compounds having good anti-tubercular activity is gaining much importance in the
field of tuberculosis research due to reemergence of antibiotic resistance strains. In this …

[HTML][HTML] Synthesis, antiviral bioactivity of novel 4-thioquinazoline derivatives containing chalcone moiety

Z Wan, D Hu, P Li, D Xie, X Gan - Molecules, 2015 - mdpi.com
A series of novel 4-thioquinazoline derivatives containing chalcone moiety were designed,
synthesized and systematically evaluated for their antiviral activity against TMV. The …

Heterocyclic chalcone analogues as potential anticancer agents

V Sharma, V Kumar, P Kumar - Anti-Cancer Agents in Medicinal …, 2013 - ingentaconnect.com
Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as
Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two …

Antioxidant and anti-inflammatory related activities of selected synthetic chalcones: structure–activity relationship studies using computational tools

R Gacche, M Khsirsagar, S Kamble… - Chemical and …, 2008 - jstage.jst.go.jp
Synthetic derivatives of 1-(2-hydroxy-3-(2-hydroxy-cyclohexyl)-4, 6-dimethoxy-phenyl)-
methanone were evaluated in-vitro for their activities related to antioxidant and anti …

[PDF][PDF] An efficient and operationally simple synthesis of some new chalcones by using grinding technique

S Zangade, S Mokle, A Vibhute, Y Vibhute - Chem Sci J, 2011 - researchgate.net
An efficient and operationally simple reaction is shown between substituted 2-acetyl-1-
naphthol/2-acetyl-1-naphthol and different substituted benzaldehydes in presence of base …

[HTML][HTML] Novel halogenated pyrazine-based chalcones as potential antimicrobial drugs

M Kucerova-Chlupacova, V Vyskovska-Tyllova… - Molecules, 2016 - mdpi.com
Chalcones, ie, compounds with the chemical pattern of 1, 3-diphenylprop-2-en-1-ones, exert
a wide range of bio-activities, eg, antioxidant, anti-inflammatory, anticancer, anti-infective …

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents

MVB Reddy, YC Shen, E Ohkoshi, KF Bastow… - European journal of …, 2012 - Elsevier
Chalcones have a distinctive 1, 3-diarylpropenone skeleton and exert numerous biological
effects. Using a one-step Claisen–Schmidt condensation, we synthesized eleven bis …

Design, synthesis, and biological evaluation of prenylated chalcones as vasorelaxant agents

X Dong, J Chen, C Jiang, T Liu… - Archiv der Pharmazie: An …, 2009 - Wiley Online Library
Five prenylated chalcones and one allylated chalcone were prepared according to the
analysis based on support vector machine (SVM) classification model. Most of the …