Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Bacteria require iron for growth, with only a few reported exceptions. In many environments,
iron is a limiting nutrient for growth and high affinity uptake systems play a central role in iron …

Bacterial outer membrane vesicles (OMVs) have important biological roles in pathogenesis
and intercellular interactions, but a general mechanism of OMV formation is lacking. Here …

The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …

Bacterial cells modulate transcription in response to changes in iron availability. The ferric
uptake regulator (Fur) senses intracellular iron availability and plays a central role in …

The six-component maintenance of lipid asymmetry (Mla) system is responsible for
retrograde transport of phospholipids, ensuring the barrier function of the Gram-negative cell …

Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global
disease that is difficult to treat and for which there is no vaccine. This pathogen employs an …

Background In the alpha subclass of proteobacteria iron homeostasis is controlled by
diverse iron responsive regulators. Caulobacter crescentus, an important freshwater α …

Iron is an essential nutrient, but it can also be toxic. Therefore, iron homeostasis must be
strictly regulated. Transcriptional control of iron-dependent gene expression in the rhizobia …

Although originally known as an opportunistic pathogen, Klebsiella pneumoniae has been
considered a worldwide health threat nowadays due to the emergence of hypervirulent and …