Bone defects characterized by limited regenerative properties are considered a priority in
surgical practice, as they are associated with reduced quality of life and high costs. In bone …

Large bone defects with limited intrinsic regenerative potential represent a major surgical
challenge and are associated with a high socio-economic burden and severe reduction in …

Iron oxide nanoparticles (IONPs) are generally used in multiple biomedical applications. The
tissue repair effect of IONPs had been demonstrated in the previous studies of our group, but …

Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

The domestication and subsequent development of sheep are crucial events in the history of
human civilization and the agricultural revolution. However, the impact of interspecific …

The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …

Objectives In pulpal revascularization, a protective material is placed coronal to the blood
clot to prevent recontamination and to facilitate osteogenic differentiation of mesenchymal …

Abstract Changes in potential regulatory elements are thought to be key drivers of
phenotypic divergence. However, identifying changes to regulatory elements that underlie …

Proper temporal epigenetic regulation of gene expression is essential for cell fate
determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was …

Stromal progenitors are found in many different tissues, where they play an important role in
the maintenance of tissue homeostasis owing to their ability to differentiate into parenchymal …