Wall shear stress and its role in atherosclerosis

M Zhou, Y Yu, R Chen, X Liu, Y Hu, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions

JJ Wentzel, YS Chatzizisis, FJH Gijsen… - Cardiovascular …, 2012 - academic.oup.com
The heterogeneity of plaque formation, the vascular remodelling response to plaque
formation, and the consequent phenotype of plaque instability attest to the extraordinarily …

Effect of rheological models on the hemodynamics within human aorta: CFD study on CT image-based geometry

S Karimi, M Dabagh, P Vasava, M Dadvar… - Journal of Non …, 2014 - Elsevier
The pulsatile blood flow through human aortic arch and three major branches are
computationally studied to investigate the effect of blood rheology on the hemodynamic …

Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation

YC Zhao, P Vatankhah, T Goh, R Michelis, K Kyanian… - Scientific reports, 2021 - nature.com
Disturbed blood flow has been increasingly recognized for its critical role in platelet
aggregation and thrombosis. Microfluidics with hump shaped contractions have been …

[HTML][HTML] Numerical analysis of the effect of turbulence transition on the hemodynamic parameters in human coronary arteries

A Mahalingam, UU Gawandalkar, G Kini… - Cardiovascular …, 2016 - ncbi.nlm.nih.gov
Background Local hemodynamics plays an important role in atherogenesis and the
progression of coronary atherosclerosis disease (CAD). The primary biological effect due to …

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

FJ Tovar-Lopez, G Rosengarten, E Westein… - Lab on a Chip, 2010 - pubs.rsc.org
This paper reports the development of a platform technology for measuring platelet function
and aggregation based on localized strain rate micro-gradients. Recent experimental …

Evaluating medical device and material thrombosis under flow: current and emerging technologies

JK Hong, L Gao, J Singh, T Goh, AM Ruhoff… - Biomaterials …, 2020 - pubs.rsc.org
Although blood-contacting medical devices are used widely, blood clot formation
(thrombosis) leads to device failure and potentially catastrophic adverse thrombotic events …

Association of blood viscosity with mortality among patients hospitalized with COVID-19

D Choi, O Waksman, A Shaik, P Mar, Q Chen… - Journal of the American …, 2022 - jacc.org
Abstract Background Coronavirus disease-2019 (COVID-19) is characterized by a
dysfunctional immune response and abnormal blood rheology that contribute to endothelial …

[HTML][HTML] Viscoelastic flow simulations in random porous media

S De, JAM Kuipers, E Peters, JT Padding - Journal of Non-Newtonian Fluid …, 2017 - Elsevier
We investigate creeping flow of a viscoelastic fluid through a three dimensional random
porous medium using computational fluid dynamics. The simulations are performed using a …

Non-Newtonian effects in simulations of coronary arterial blood flow

AJ Apostolidis, AP Moyer, AN Beris - Journal of Non-Newtonian Fluid …, 2016 - Elsevier
We present a careful evaluation of non-Newtonian blood rheology effects in arterial flow
simulations. We achieve that by comparing the converged solutions obtained a) from a …