Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves
an important scaffolding role at focal adhesions by recruiting structural and signaling …

Cell‐surface engineering holds great promise in boosting endogenous stem cell attraction
for tissue regeneration. However, challenges such as cellular internalization of ligand and …

Summary 3D amoeboid cell migration is central to many developmental and disease-related
processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell …

Material surface topographic features have been shown to be crucial for tissue regeneration
and surface treatment of implanted devices. Many biomaterials were investigated with …

Integrin-based adhesion has served as a model for studying the central role of adhesion in
migration. In this article, we outline modes of migration, both integrin-dependent and …

The mammalian TOR (mTOR) pathway integrates nutrient-and growth factor-derived signals
to regulate growth, the process whereby cells accumulate mass and increase in size. mTOR …

A central question in cell biology is how membrane-spanning receptors transmit
extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion …

Metastasis is a major cause of death in cancer patients and involves a multistep process
including detachment of cancer cells from a primary cancer, invasion of surrounding tissue …

Cell migration is a complex, highly regulated process that involves the continuous formation
and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the …