Fish are the most diversified group of vertebrates and, although progress has been made in
the past years, only relatively few fish species have been examined to date, with regards to …

Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …

The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …

Importance Biologic systems involved in the regulation of motor activity are intricately linked
with other homeostatic systems such as sleep, feeding behavior, energy, and mood. Mobile …

Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular
function of sleep is unknown, and there is no conserved molecular marker to define sleep …

Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the
orexin system is particularly important for maintenance of wakefulness. However, orexin …

Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as
endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They …

Circadian and homeostatic neural circuits organize the temporal architecture of physiology
and behavior, but knowledge of their interactions is imperfect. For example, neurons …

The zebrafish larva stands out as an emergent model organism for translational studies
involving gene or drug screening thanks to its size, genetics, and permeability. At the larval …