The search for noise-induced cochlear synaptopathy in humans: Mission impossible?
N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …
Olivocochlear efferents in animals and humans: from anatomy to clinical relevance
EA Lopez-Poveda - Frontiers in neurology, 2018 - frontiersin.org
Olivocochlear efferents allow the central auditory system to adjust the functioning of the
inner ear during active and passive listening. While many aspects of efferent anatomy …
inner ear during active and passive listening. While many aspects of efferent anatomy …
Toward a differential diagnosis of hidden hearing loss in humans
MC Liberman, MJ Epstein, SS Cleveland, H Wang… - PloS one, 2016 - journals.plos.org
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …
Individual differences reveal correlates of hidden hearing deficits
HM Bharadwaj, S Masud, G Mehraei… - Journal of …, 2015 - Soc Neuroscience
Clinical audiometry has long focused on determining the detection thresholds for pure tones,
which depend on intact cochlear mechanics and hair cell function. Yet many listeners with …
which depend on intact cochlear mechanics and hair cell function. Yet many listeners with …
Auditory brainstem response latency in noise as a marker of cochlear synaptopathy
Evidence from animal and human studies suggests that moderate acoustic exposure,
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …
Cochlear neuropathy and the coding of supra-threshold sound
HM Bharadwaj, S Verhulst, L Shaheen… - Frontiers in systems …, 2014 - frontiersin.org
Many listeners with hearing thresholds within the clinically normal range nonetheless
complain of difficulty hearing in everyday settings and understanding speech in noise …
complain of difficulty hearing in everyday settings and understanding speech in noise …
Synaptopathy in the aging cochlea: Characterizing early-neural deficits in auditory temporal envelope processing
A Parthasarathy, SG Kujawa - Journal of Neuroscience, 2018 - Soc Neuroscience
Aging listeners, even in the absence of overt hearing loss measured as changes in hearing
thresholds, often experience impairments processing temporally complex sounds such as …
thresholds, often experience impairments processing temporally complex sounds such as …
Auditory function in normal-hearing, noise-exposed human ears
GC Stamper, TA Johnson - Ear and hearing, 2015 - journals.lww.com
Objectives: To determine whether suprathreshold measures of auditory function, such as
distortion-product otoacoustic emissions (DPOAEs) and auditory brainstem responses …
distortion-product otoacoustic emissions (DPOAEs) and auditory brainstem responses …
[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …
Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing
A Parthasarathy, KE Hancock, K Bennett, V DeGruttola… - Elife, 2020 - elifesciences.org
In social settings, speech waveforms from nearby speakers mix together in our ear canals.
Normally, the brain unmixes the attended speech stream from the chorus of background …
Normally, the brain unmixes the attended speech stream from the chorus of background …