The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Olivocochlear efferents in animals and humans: from anatomy to clinical relevance

EA Lopez-Poveda - Frontiers in neurology, 2018 - frontiersin.org
Olivocochlear efferents allow the central auditory system to adjust the functioning of the
inner ear during active and passive listening. While many aspects of efferent anatomy …

Toward a differential diagnosis of hidden hearing loss in humans

MC Liberman, MJ Epstein, SS Cleveland, H Wang… - PloS one, 2016 - journals.plos.org
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

Individual differences reveal correlates of hidden hearing deficits

HM Bharadwaj, S Masud, G Mehraei… - Journal of …, 2015 - Soc Neuroscience
Clinical audiometry has long focused on determining the detection thresholds for pure tones,
which depend on intact cochlear mechanics and hair cell function. Yet many listeners with …

Auditory brainstem response latency in noise as a marker of cochlear synaptopathy

G Mehraei, AE Hickox, HM Bharadwaj… - Journal of …, 2016 - Soc Neuroscience
Evidence from animal and human studies suggests that moderate acoustic exposure,
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …

Cochlear neuropathy and the coding of supra-threshold sound

HM Bharadwaj, S Verhulst, L Shaheen… - Frontiers in systems …, 2014 - frontiersin.org
Many listeners with hearing thresholds within the clinically normal range nonetheless
complain of difficulty hearing in everyday settings and understanding speech in noise …

Synaptopathy in the aging cochlea: Characterizing early-neural deficits in auditory temporal envelope processing

A Parthasarathy, SG Kujawa - Journal of Neuroscience, 2018 - Soc Neuroscience
Aging listeners, even in the absence of overt hearing loss measured as changes in hearing
thresholds, often experience impairments processing temporally complex sounds such as …

Auditory function in normal-hearing, noise-exposed human ears

GC Stamper, TA Johnson - Ear and hearing, 2015 - journals.lww.com
Objectives: To determine whether suprathreshold measures of auditory function, such as
distortion-product otoacoustic emissions (DPOAEs) and auditory brainstem responses …

[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

H Guest, KJ Munro, G Prendergast, RE Millman… - Hearing research, 2018 - Elsevier
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …

Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing

A Parthasarathy, KE Hancock, K Bennett, V DeGruttola… - Elife, 2020 - elifesciences.org
In social settings, speech waveforms from nearby speakers mix together in our ear canals.
Normally, the brain unmixes the attended speech stream from the chorus of background …