The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …

Major depressive disorder (MDD) is a severe mood disorder and frequently associated with
alterations of the immune system characterized by enhanced levels of circulating pro …

An important aspect of survival is to assure enough food, water, and oxygen. Here, we
describe a recently discovered response that favors survival in times of scarcity, and it is …

Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more
severe and less responsive to treatment in obese subjects. While alterations in …

It is now becoming clear that human metabolism is extremely plastic and varies substantially
between healthy individuals. Understanding the biochemistry that underlies this physiology …

Measurement of skeletal muscle mitochondrial respiration requires invasive biopsy to obtain
a muscle sample. Peripheral blood mononuclear cell (PBMC) mitochondrial protein content …

Mitochondrial bioenergetic function is a central component of cellular metabolism in health
and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic …

Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of
megakaryocytes and have a unique metabolic phenotype compared with circulating …