[HTML][HTML] Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
D Nolfi-Donegan, A Braganza, S Shiva - Redox biology, 2020 - Elsevier
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …
generate cellular ATP through oxidative phosphorylation. A consequence of electron …
Mitochondria as a therapeutic target for common pathologies
MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
Integrating mitochondrial aerobic metabolism into ecology and evolution
Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …
variation in performance and fitness among individuals. Whole-organism metabolic studies …
Mitochondria, microglia, and the immune system—how are they linked in affective disorders?
Major depressive disorder (MDD) is a severe mood disorder and frequently associated with
alterations of the immune system characterized by enhanced levels of circulating pro …
alterations of the immune system characterized by enhanced levels of circulating pro …
[HTML][HTML] Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
An important aspect of survival is to assure enough food, water, and oxygen. Here, we
describe a recently discovered response that favors survival in times of scarcity, and it is …
describe a recently discovered response that favors survival in times of scarcity, and it is …
Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets
D Winnica, C Corey, S Mullett, M Reynolds… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more
severe and less responsive to treatment in obese subjects. While alterations in …
severe and less responsive to treatment in obese subjects. While alterations in …
Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine
It is now becoming clear that human metabolism is extremely plastic and varies substantially
between healthy individuals. Understanding the biochemistry that underlies this physiology …
between healthy individuals. Understanding the biochemistry that underlies this physiology …
Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men
CP Hedges, JST Woodhead… - Journal of applied …, 2019 - journals.physiology.org
Measurement of skeletal muscle mitochondrial respiration requires invasive biopsy to obtain
a muscle sample. Peripheral blood mononuclear cell (PBMC) mitochondrial protein content …
a muscle sample. Peripheral blood mononuclear cell (PBMC) mitochondrial protein content …
Utilization of human samples for assessment of mitochondrial bioenergetics: Gold standards, limitations, and future perspectives
R Acin-Perez, C Benincá, B Shabane, OS Shirihai… - Life, 2021 - mdpi.com
Mitochondrial bioenergetic function is a central component of cellular metabolism in health
and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic …
and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic …
Regulation of mitochondrial function as a promising target in platelet activation-related diseases
Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of
megakaryocytes and have a unique metabolic phenotype compared with circulating …
megakaryocytes and have a unique metabolic phenotype compared with circulating …