Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many
diseases, that sensitizes nociceptors through its action on a variety of ion channels …

Pain is the leading symptom for most individuals with osteoarthritis (OA), a complex
condition marked by joint discomfort. Recently, the dynamic interplay between the nervous …

The sensitization and hypertonicity of visceral afferents are highly relevant to the
development and progression of cardiovascular and respiratory disease states. In this …

Background Our aim was attempting to find proteins involved in the pain process and
correlating with pain but not degree of inflammation in children with juvenile idiopathic …

Nociceptive innervation of the thoracolumbar fascia (TLF) has been investigated over the
past few decades; however, these studies have not been compiled or collectively appraised …

The rationale for using thalidomide (THD) as a treatment for nausea and vomiting during
pregnancy in the late 1950s appears to have been based on its sedative or hypnotic …

Decrease of glutamate transporter-1 (GLT-1) in the spinal dorsal horn after nerve injury
induces enhanced excitatory transmission and causes persistent pain. Histone deacetylases …

Objective and design Our aim was to determine an age-dependent role of Nav1. 8 and
ASIC3 in dorsal root ganglion (DRG) neurons in a rat pre-clinical model of long-term …