[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
[HTML][HTML] Genetic markers in triple-negative breast cancer
Z Sporikova, V Koudelakova, R Trojanec… - Clinical breast cancer, 2018 - Elsevier
Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancer cases and
is characterized by the absence of estrogen, progesterone, and human epidermal growth …
is characterized by the absence of estrogen, progesterone, and human epidermal growth …
[HTML][HTML] Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study
Background Retrospective studies provide conflicting interpretations of the effect of inherited
genetic factors on the prognosis of patients with breast cancer. The primary aim of this study …
genetic factors on the prognosis of patients with breast cancer. The primary aim of this study …
Mechanisms of immune evasion in breast cancer
Tumors develop multiple mechanisms of immune evasion as they progress, with some
cancer types being inherently better at 'hiding'than others. With an increased understanding …
cancer types being inherently better at 'hiding'than others. With an increased understanding …
Association of cell-free DNA tumor fraction and somatic copy number alterations with survival in metastatic triple-negative breast cancer
Purpose Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide
profiling of tumor alterations without tumor biopsy and may be associated with patient …
profiling of tumor alterations without tumor biopsy and may be associated with patient …
Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments
U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …
million new cases in world in 2018. It is the second leading cause of death from cancer in …
Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy
S Loizides, A Constantinidou - Frontiers in genetics, 2023 - frontiersin.org
Triple negative breast cancer (TNBC) is a biologically diverse subtype of breast cancer
characterized by genomic and transcriptional heterogeneity and exhibiting aggressive …
characterized by genomic and transcriptional heterogeneity and exhibiting aggressive …
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient
breast tumors caused by genetic or epigenetic alterations in key pathway genes. We …
breast tumors caused by genetic or epigenetic alterations in key pathway genes. We …
Association between genomic metrics and immune infiltration in triple-negative breast cancer
Importance Why some triple-negative breast cancers (TNBCs) have high and others have
low immune cell infiltration is unknown. Understanding how immune surveillance shapes …
low immune cell infiltration is unknown. Understanding how immune surveillance shapes …
Immune gene expression is associated with genomic aberrations in breast cancer
The presence of tumor-infiltrating lymphocytes (TIL) is a favorable prognostic factor in breast
cancer, but what drives immune infiltration remains unknown. Here we examine if clonal …
cancer, but what drives immune infiltration remains unknown. Here we examine if clonal …