Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

The application of pharmacogenetics holds great promise for individualized therapy.
However, it has little clinical reality at present, despite many claims. The main problem is that …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of
clinically important drugs (eg, clozapine, tacrine, tizanidine, and theophylline), a number of …

A critical review of the limited available evidence and the authors' experience and judgment
are used to summarize the role of cytochrome P450 (CYP) genetic variants in the …

Isoniazid, administered as part of combination antituberculosis therapy, is responsible for
most of the early bactericidal activity (EBA) of the regimen. However, the emergence of …

Several antihistamine drugs including terfenadine, ebastine, and astemizole have been
identified as substrates for CYP2J2. The overall importance of this enzyme in drug …