[HTML][HTML] The redox interplay between nitrite and nitric oxide: From the gut to the brain

C Pereira, NR Ferreira, BS Rocha, RM Barbosa… - Redox biology, 2013 - Elsevier
The reversible redox conversion of nitrite and nitric oxide (radical dot NO) in a physiological
setting is now widely accepted. Nitrite has long been identified as a stable intermediate of …

[HTML][HTML] The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration

A Ledo, CF Lourenço, E Cadenas, RM Barbosa… - Free Radical Biology …, 2021 - Elsevier
The small and diffusible free radical nitric oxide (• NO) has fascinated biological and medical
sciences since it was promoted from atmospheric air pollutant to biological ubiquitous …

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor

A Ledo, RM Barbosa, GA Gerhardt… - Proceedings of the …, 2005 - National Acad Sciences
Nitric oxide () production in response to stimulation of the NMDA glutamate receptor is
implicated not only in the synaptic plasticity in hippocampus but may also participate in …

Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions

A Ledo, J Frade, RM Barbosa, J Laranjinha - Molecular aspects of medicine, 2004 - Elsevier
Nitric oxide (NO) is a diffusible regulatory molecule involved in a wide range of physiological
and pathological events. At the tissue level, a local and temporary increase in NO …

In vivo real‐time measurement of nitric oxide in anesthetized rat brain

RM Barbosa, CF Lourenço, RM Santos… - Methods in …, 2008 - Elsevier
During the last two decades nitric oxide (· NO) gas has emerged as a novel and ubiquitous
intercellular modulator of cell functions. In the brain,· NO is implicated in mechanisms of …

A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue

RM Santos, CF Lourenço, AP Piedade… - Biosensors and …, 2008 - Elsevier
The measurement of Nitric oxide (NO) in real-time has been a major concern due to the
involvement of this ubiquitous free radical modulator in several physiological and …

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for …

C Dias, CF Lourenço, E Ferreiro, RM Barbosa… - Neurobiology of …, 2016 - Elsevier
Age-dependent changes in nitric oxide (• NO) concentration dynamics may play a significant
role in both decaying synaptic and metabolic functions in Alzheimer's disease (AD). This …

Nitric oxide signaling is disrupted in the yeast model for Batten disease

NS Osorio, A Carvalho, AJ Almeida… - Molecular biology of …, 2007 - Am Soc Cell Biol
The juvenile form of neuronal ceroid lipofuscinoses (JNCLs), or Batten disease, results from
mutations in the CLN3 gene, and it is characterized by the accumulation of lipopigments in …

Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes

NR Ferreira, A Ledo, JG Frade, GA Gerhardt… - Analytica Chimica …, 2005 - Elsevier
The role of nitric oxide (NO) as a regulatory diffusible molecule in the brain requires the
evaluation of its concentration dynamics. In this work, we have developed microelectrodes …

Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices

JG Frade, RM Barbosa, J Laranjinha - Hippocampus, 2009 - Wiley Online Library
Nitric oxide (• NO) is an intercellular messenger implicated in memory formation and
neurodegeneration in the hippocampus. Owing to its physical and chemical properties, the …