MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae

A Fleurie, C Lesterlin, S Manuse, C Zhao, C Cluzel… - Nature, 2014 - nature.com
In every living organism, cell division requires accurate identification of the division site and
placement of the division machinery. In bacteria, this process is traditionally considered to …

[HTML][HTML] A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches

P Radler, M Loose - European Journal of Cell Biology, 2023 - Elsevier
Bacteria divide by binary fission. The protein machine responsible for this process is the
divisome, a transient assembly of more than 30 proteins in and on the surface of the …

A simplified curcumin targets the membrane of Bacillus subtilis

LG Morão, CR Polaquini, M Kopacz… - …, 2019 - Wiley Online Library
Curcumin is the main constituent of turmeric, a seasoning popularized around the world with
Indian cuisine. Among the benefits attributed to curcumin are anti‐inflammatory …

[HTML][HTML] Antibacterial activity of alkyl gallates is a combination of direct targeting of FtsZ and permeabilization of bacterial membranes

E Król, A de Sousa Borges, I da Silva… - Frontiers in …, 2015 - frontiersin.org
Alkyl gallates are compounds with reported antibacterial activity. One of the modes of action
is binding of the alkyl gallates to the bacterial membrane and interference with membrane …

Cell division protein FtsZ is unfolded for N-terminal degradation by antibiotic-activated ClpP

N Silber, S Pan, S Schäkermann, C Mayer… - MBio, 2020 - Am Soc Microbiol
ABSTRACT Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of
the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating …

Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ

AM Hogan, VC Scoffone, V Makarov… - Antimicrobial agents …, 2018 - Am Soc Microbiol
To streamline the elucidation of antibacterial compounds' mechanism of action,
comprehensive high-throughput assays interrogating multiple putative targets are …

Antibacterial activity of 3, 3′-dihydroxycurcumin (DHC) is associated with membrane perturbation

CR Polaquini, LG Morão, AC Nazaré, GS Torrezan… - Bioorganic …, 2019 - Elsevier
Curcumin is a plant diphenylheptanoid and has been investigated for its antibacterial
activity. However, the therapeutic uses of this compound are limited due to its chemical …

Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption

CR Polaquini, BC Marques, GM Ayusso, LG Morão… - Bioorganic …, 2021 - Elsevier
Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the
other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic …

[HTML][HTML] The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division

G Degiacomi, LR Chiarelli, O Riabova, NI Loré… - International Journal of …, 2024 - Elsevier
Aims The incidence of lung infections is increasing worldwide in individuals suffering from
cystic fibrosis and chronic obstructive pulmonary diseases. Mycobacterium abscessus is …

[HTML][HTML] Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool

N Silber, C Mayer, CL Matos de Opitz… - Communications …, 2021 - nature.com
Cell division is a central and essential process in most bacteria, and also due to its
complexity and highly coordinated nature, it has emerged as a promising new antibiotic …