MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae
A Fleurie, C Lesterlin, S Manuse, C Zhao, C Cluzel… - Nature, 2014 - nature.com
In every living organism, cell division requires accurate identification of the division site and
placement of the division machinery. In bacteria, this process is traditionally considered to …
placement of the division machinery. In bacteria, this process is traditionally considered to …
[HTML][HTML] A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches
Bacteria divide by binary fission. The protein machine responsible for this process is the
divisome, a transient assembly of more than 30 proteins in and on the surface of the …
divisome, a transient assembly of more than 30 proteins in and on the surface of the …
A simplified curcumin targets the membrane of Bacillus subtilis
LG Morão, CR Polaquini, M Kopacz… - …, 2019 - Wiley Online Library
Curcumin is the main constituent of turmeric, a seasoning popularized around the world with
Indian cuisine. Among the benefits attributed to curcumin are anti‐inflammatory …
Indian cuisine. Among the benefits attributed to curcumin are anti‐inflammatory …
[HTML][HTML] Antibacterial activity of alkyl gallates is a combination of direct targeting of FtsZ and permeabilization of bacterial membranes
E Król, A de Sousa Borges, I da Silva… - Frontiers in …, 2015 - frontiersin.org
Alkyl gallates are compounds with reported antibacterial activity. One of the modes of action
is binding of the alkyl gallates to the bacterial membrane and interference with membrane …
is binding of the alkyl gallates to the bacterial membrane and interference with membrane …
Cell division protein FtsZ is unfolded for N-terminal degradation by antibiotic-activated ClpP
N Silber, S Pan, S Schäkermann, C Mayer… - MBio, 2020 - Am Soc Microbiol
ABSTRACT Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of
the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating …
the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating …
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ
To streamline the elucidation of antibacterial compounds' mechanism of action,
comprehensive high-throughput assays interrogating multiple putative targets are …
comprehensive high-throughput assays interrogating multiple putative targets are …
Antibacterial activity of 3, 3′-dihydroxycurcumin (DHC) is associated with membrane perturbation
CR Polaquini, LG Morão, AC Nazaré, GS Torrezan… - Bioorganic …, 2019 - Elsevier
Curcumin is a plant diphenylheptanoid and has been investigated for its antibacterial
activity. However, the therapeutic uses of this compound are limited due to its chemical …
activity. However, the therapeutic uses of this compound are limited due to its chemical …
Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption
CR Polaquini, BC Marques, GM Ayusso, LG Morão… - Bioorganic …, 2021 - Elsevier
Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the
other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic …
other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic …
[HTML][HTML] The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division
Aims The incidence of lung infections is increasing worldwide in individuals suffering from
cystic fibrosis and chronic obstructive pulmonary diseases. Mycobacterium abscessus is …
cystic fibrosis and chronic obstructive pulmonary diseases. Mycobacterium abscessus is …
[HTML][HTML] Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool
N Silber, C Mayer, CL Matos de Opitz… - Communications …, 2021 - nature.com
Cell division is a central and essential process in most bacteria, and also due to its
complexity and highly coordinated nature, it has emerged as a promising new antibiotic …
complexity and highly coordinated nature, it has emerged as a promising new antibiotic …