HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

New genetic models that target the serotonin system show that transient alterations in
serotonin homeostasis cause permanent changes to adult behaviour and modify the fine …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Background & Aims Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within
enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate …

An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food …

Chronic itch is a prevalent and debilitating condition for which few effective therapies are
available. We harnessed the natural variation across genetically distinct mouse strains to …

Neurons in the brainstem implicated in the initiation of locomotion include glutamatergic,
noradrenergic (NA), dopaminergic (DA), and serotonergic (5-HT) neurons giving rise to …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

Rationale Amisulpride is approved for clinical use in treating schizophrenia in a number of
European countries and also for treating dysthymia, a mild form of depression, in Italy …

Background: The aim of this review was to identify the mechanisms by which serotonin
receptors involved at the central level are able to modulate the nociceptive response. Pain is …