Circulating tumor cell isolation for cancer diagnosis and prognosis
Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …
Aptamer-based detection of circulating targets for precision medicine
L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
Nucleic acid aptamers for molecular diagnostics and therapeutics: advances and perspectives
The advent of SELEX (systematic evolution of ligands by exponential enrichment)
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …
Molecular identification of tumor-derived extracellular vesicles using thermophoresis-mediated DNA computation
Molecular profiling of tumor-derived extracellular vesicles (tEVs) holds great promise for non-
invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is …
invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is …
Deterministic lateral displacement: Challenges and perspectives
The advent of microfluidics in the 1990s promised a revolution in multiple industries from
healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous …
healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous …
Automated coupling of nanodroplet sample preparation with liquid chromatography–mass spectrometry for high-throughput single-cell proteomics
Single-cell proteomics can provide critical biological insight into the cellular heterogeneity
that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet …
that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet …
Fluidic multivalent membrane nanointerface enables synergetic enrichment of circulating tumor cells with high efficiency and viability
The ubiquitous biomembrane interface, with its dynamic lateral fluidity, allows membrane-
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …
DNA framework-programmed cell capture via topology-engineered receptor–ligand interactions
Receptor–ligand interactions (RLIs) that play pivotal roles in living organisms are often
depicted with the classic keys-and-locks model. Nevertheless, RLIs on the cell surface are …
depicted with the classic keys-and-locks model. Nevertheless, RLIs on the cell surface are …