Tumours with mutations in the BRCA1/BRCA2 genes have impaired double-stranded DNA
break repair, compromised replication fork protection and increased sensitivity to replication …

BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …

Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in …

Older age is a strong risk factor for several diseases, including cancer. The etiology and
biology of age-associated differences among cancers are poorly understood. To address …

PURPOSE Among patients with metastatic breast cancer (mBC), the frequency of germline
mutations in cancer susceptibility genes and the clinical relevance of these mutations are …

The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled
replication forks, which leads to replication‐associated DNA damage and genomic …

Abstract Analysis of human cancer genome sequences has revealed specific mutational
signatures associated with BRCA1-deficient tumors, but the underlying mechanisms remain …

Background: Structural variations (SVs) are common genetic alterations in the human
genome. However, the profile and clinical relevance of SVs in patients with hereditary breast …

In the age of precision medicine, extensive research has investigated tumour biomarkers to
predict the behaviour of cancer and/or response to treatment in order to better understand …

Purpose Homologous recombination deficiency (HRD) is related to tumorigenesis.
Currently, the possibility of HRD as a prognostic biomarker to immune checkpoint inhibitors …