Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …