Optical imaging of live animals has grown into an important tool in biomedical research as
advances in photonic technology and reporter strategies have led to widespread exploration …

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

Fluorescence microscopic imaging is widely used in biomedical research to study molecular
and cellular processes in cell culture or tissue samples. This is motivated by the high …

This article reviews the past and current statuses of time-domain near-infrared spectroscopy
(TD-NIRS) and imaging. Although time-domain technology is not yet widely employed due to …

Abstract According to World Health Organization estimates, infectious organisms are
responsible for approximately one in four deaths worldwide. Animal models play an …

Imaging of targeted fluorescent probes offers significant advantages for investigating
disease and tissue function in animal models in vivo. Conversely, macroscopic tomographic …

We present a novel technique for wide dynamic range optical investigations. It is based on a
fast-gated silicon single-photon avalanche diode (SPAD) in time-correlated single-photon …

A general linear model for time domain (TD) fluorescence tomography is presented that
allows a lifetime-based analysis of the entire temporal fluorescence response from a turbid …

We have designed a compact dual wavelength multi-channel time-resolved system for
functional near infrared spectroscopy. The system enables 16 sources and up to 64 …

We present a time-domain optical system for functional imaging of the adult head. We first
describe the instrument, which is based on a Ti: Sapphire pulsed laser (wavelength 750 …