Chronic cough is globally prevalent across all age groups. This disorder is challenging to
treat because many pulmonary and extrapulmonary conditions can present with chronic …

Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Background Gefapixant is an oral P2X 3 receptor antagonist that has previously shown
efficacy and safety in refractory chronic cough and unexplained chronic cough. We therefore …

These guidelines incorporate the recent advances in chronic cough pathophysiology,
diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella …

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic
airway diseases that have a high personal and social impact. They likely represent a …

Background Gefapixant is a P2X3 receptor antagonist that has shown promise for the
treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate …

Cough is an essential defence mechanism [1]. However, chronic cough is a significant
cause of morbidity, seriously impairing quality of life [2]. Previously, chronic cough was …

Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Reports from individual centres suggest a preponderance of females with chronic cough.
Females also have heightened cough reflex sensitivity. Here we have reviewed the age and …

We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge.
In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy …