SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Ubiquitylation is a widely used post-translational protein modification that regulates many
biological processes, including immune responses. The role of ubiquitin in immune …

The assembly and activation of the inflammasomes are tightly regulated by post‐
translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

The histone demethylase PHF8 has been implicated in multiple pathological disorders,
including X-linked mental retardation and tumorigenesis. However, it is not clear how the …

Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase.
HAUSP is a protein of immense biological importance as it is involved in several cellular …

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …

Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and
programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric …