[HTML][HTML] Selective induction of programmed cell death using synthetic biology tools
K Shkarina, P Broz - Seminars in cell & developmental biology, 2023 - Elsevier
Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells,
and is thus essential for development, homeostasis and immunity of multicellular organisms …
and is thus essential for development, homeostasis and immunity of multicellular organisms …
Gene therapy for infectious diseases
BA Bunnell, RA Morgan - Clinical microbiology reviews, 1998 - Am Soc Microbiol
Gene therapy is being investigated as an alternative treatment for a wide range of infectious
diseases that are not amenable to standard clinical management. Approaches to gene …
diseases that are not amenable to standard clinical management. Approaches to gene …
Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.
The herpes simplex virus type 1 thymidine kinase (HSV1-TK) converts nontoxic nucleoside
analogs such as ganciclovir into phosphorylated compounds that act as chain terminators …
analogs such as ganciclovir into phosphorylated compounds that act as chain terminators …
Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody.
L Duan, O Bagasra, MA Laughlin… - Proceedings of the …, 1994 - National Acad Sciences
Human immunodeficiency virus type 1 (HIV-1) has a complex life cycle, which has made it a
difficult target for conventional therapeutic modalities. A single-chain antibody moiety …
difficult target for conventional therapeutic modalities. A single-chain antibody moiety …
[PDF][PDF] Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Thymidylate kinase (TmpK) is an essential enzyme for cell replication. TmpK (EC 2.749; ATP
dTMP phosphotransferase) phosphorylates thymidine mono-phos-phate (dTMP) to the …
dTMP phosphotransferase) phosphorylates thymidine mono-phos-phate (dTMP) to the …
Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting
W Walther, U Stein - Journal of Molecular Medicine, 1996 - Springer
Gene therapy is used to correct genetic defects or to deliver new therapeutic functions to the
target cells. Viral vectors are employed mainly as a gene delivery system. A great variety of …
target cells. Viral vectors are employed mainly as a gene delivery system. A great variety of …
The role of the bystander effect in suicide gene therapy
IM Pope, GJ Poston, AR Kinsella - European Journal of Cancer, 1997 - Elsevier
IN RECENT years, a combination of cytogenetic and molecular techniques has allowed the
identification of the precise genetic alterations that underlie the stepwise progression to …
identification of the precise genetic alterations that underlie the stepwise progression to …
Metabolic suicide genes in gene therapy
CA Mullen - Pharmacology & therapeutics, 1994 - Elsevier
This article reviews uses of metabolic suicide genes in gene therapy. Suicide genes encode
novel nonmammalian enzyme that can convert a relatively nontoxic prodrug into a highly …
novel nonmammalian enzyme that can convert a relatively nontoxic prodrug into a highly …
Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments
Abstract Suicide Gene Therapy (SGT) aims to introduce a gene encoding either a toxin or an
enzyme making the targeted cell more sensitive to chemotherapy. SGT represents an …
enzyme making the targeted cell more sensitive to chemotherapy. SGT represents an …
Cell and gene therapy for HIV cure
CW Peterson, HP Kiem - HIV-1 latency, 2017 - Springer
As the HIV pandemic rapidly spread worldwide in the 1980s and 1990s, a new approach to
treat cancer, genetic diseases, and infectious diseases was also emerging. Cell and gene …
treat cancer, genetic diseases, and infectious diseases was also emerging. Cell and gene …